About the Stelzer Lab

Systems, Reproductive, and Neuroimmunology of Pregnancy

Our lab focuses on the complex maternal neuroimmune adaptations during pregnancy. The maternal immune system has established mechanisms to tolerate the semiallogeneic fetus while supporting its growth and development. Disruptions in these adaptations are linked to complications throughout the peripartum period. Advancing our understanding of maternal health is essential for improving outcomes for both pregnant women and their children.

Our primary research goal is to explore the interactions between the uterus and the maternal brain during the peripartum period. We are particularly interested in uncovering how communication between the peripheral and central nervous and immune systems adapts during the transition to motherhood.

By characterizing the neuroimmune pathways that enable the maternal brain to recognize the fetus—and, conversely, facilitate central-to-peripheral signaling to the uterus—we aim to advance knowledge on how the maternal body supports pregnancy. This research has the potential to illuminate mechanisms underlying both healthy outcomes and complications, such as spontaneous preterm birth and perinatal depression.

We leverage our expertise in translational systems immunology to bridge research on human pregnancy cohorts with preclinical (mouse) models of pregnancy. Our work seeks to uncover fundamental biological processes, identify biomarkers, and lay the groundwork for preventative and therapeutic strategies to improve both short- and long-term health outcomes for pregnant individuals.