About Dr. Ferguson
Dr. Ferguson is member of the Neurosciences graduate program as well as the Biomedical Sciences graduate program (Cell & Developmental Biology and Genetics & Genomics). We are looking to recruit curious and motivated graduate students. If you are interested in rotating through the lab or joining, please contact Dr. Ferguson.
Welcome to the Ferguson Lab!
A molecular neuroscience lab, we study how genes regulate of the development and function of the mammalian brain. We use genetically-engineered mutant mice to understand how defects in chromatin regulation contribute to human neurodevelopmental disorders such as the ANAPC7 neurodevelopmental syndrome. In pursuit of these goals, we employ a wide range of experimental methods that range from genomics, imaging, biochemistry and behavior. We also have close collaborations with expert labs in bioinformatics, proteomics, structural biology and human genetics.
Research Findings
High-resolution chromatin mapping using the 1-dimensional method CUT and RUN (Cleavage Under Targets and Release Using Nuclease) and 2-dimensional method micro-C.
Quantitative TMT-MS proteomics identifications of the APC substrate Ki-67 in neurons of mutant mice with impaired APC-mediated protein clearance.
High-resolution imaging methods to explore the regulation of constitutive heterochromatin by the highly disordered APC substrate Ki-67.