Xiangdong "Don" Xu, M.D., Ph.D.

Mark Valasek, M.D., Ph.D.

  • Associate Professor
  • Site Director for Medical Education, VAMC
  • Director of Hematology & Coagulation Laboratory
  • Co-Director of Immunogenetics and Flow Cytometry
  • M.D. – Peking Union Medical College, Beijing China
  • Ph.D. – University of California, San Diego, La Jolla CA
  • Postdoctoral Fellow: Salk Institute for Biological Studies
  • Residency Training: University of California, San Diego
  • Fellowship Training: Washington University in St. Louis, MO
  • Board Certifications: Anatomic and Clinical Pathology, Hematopathology
  • Subspecialty: Hematopathology, Flow Cytometry, and Surgical Pathology

Research Interests

Myelodysplastic syndrome, lymphoma, leukemia, prostate cancer, cancer immunotherapy

Representative Publications

  1. Sun J, Lei L, Tsai CM, Wang Y, Shi Y, Ouyang M, Lu S, Seong J, Kim TJ, Wang P, Huang M, Xu X, Nizet V, Chien S, Wang Y. (2017) Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions. Nat Commun. 8(1):477.
  2. Hodkoff A, Bentley P, Xu X. (2017) Loss of CD3 and TCRγδ expression in a relapsed hepatosplenic T-cell lymphoma. Leuk Lymphoma 2:1-3.
  3. Thung I, Mahooti S, Xu X. (2017) A case of intra-articular angioleiomyoma of the talocrural joint. Joints 4(4):253-255.
  4. Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M. (2016) Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nature Cell Biol 18(10):1090-1101. 
  5. Liao X, Haghighi P, Coffey CS, Xu X. (2016) A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation. Rare Tumors 8(2):66-68.
  6. Perez-Alvarez I, Yekezare S, Zhao XF, Xu X. (2015) Atypical presentation of Whipple Disease with no diarrhea. Indian J Pathol Microbiol 58(3):398-399.
  7. Thung I and Xu X. (2015) Orange-colored Russell bodies by Papanicolaou stain. Blood 125(7):1198.
  8. Smith J, Wen F, Cao J, Xu X. (2014) Primary Parotid Gland Follicular Lymphoma Lacking both Cytoplasmic and Surface Immunoglobulin Light Chains: A Rare Case. Int J Clin Exp Pathol 7(10):7100-7104.
  9. Xu X, Su M, Levy NB, Kaur P, Garcia R, Mohtashamian A, Broome EH, Dell’Aquila ML, Wang HY. (2014) Myeloid Neoplasia with t(3;8)(q26;q24): Report of Six Cases and Review of the Literature. Leuk Lymphoma, 55(11):2532-2537.
  10. Xu X. (2014) Nuclear hypersegmentation of neutrophils, eosinophils, and basophils due to hydroxycarbamide (hydroxyurea). Blood, 124(9):1392.
  11. Xu X, and Hassan A. (2014) Extranodal Marginal Zone Lymphoma Arising in a Chronic Myelogenous Leukemia Patient on Long-Term Tyrosine Kinase Inhibitors. Leuk Lymphoma 55(3): 715-717.
  12. Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage FH. (2007) Alternative splicing events identified in human Embryonic Stem cells and neural progenitors. PLoS Comput Biol 3(10):1951-1967.
  13. Xu X and Fu XD. (2005) Conditional knockout mice to study alternative splicing in vivo. Methods 37(4):387-392.
  14. Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR Jr, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J Jr, Chen J, Xiao RP, Cheng H, Fu XD. (2005) ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell 120(1):59-72. (Cover article)
  15. Wang HY, Xu X, Ding JH, Bermingham JR Jr, Fu XD. (2001) SC35 plays a role in T cell development and alternative splicing of CD45. Mol Cell 7(2):331-342.

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Dr. Xu received his Doctor of Medicine degree from Peking Union Medical College and his Ph.D. degree in Biomedical Sciences from the University of California, San Diego (UCSD).  From 2005 to 2008, Dr. Xu was a postdoctoral fellow in Dr. Fred Gage’s laboratory at the Salk Institute, studying alternative splicing regulation in human and murine neural stem cells.

From 2008 to 2012, he completed the training in the Anatomic and Clinical Pathology at UCSD Medical Center.  During 2011-2012, Dr. Xu has served as the Chief Resident in Pathology. During 2012-2013, Dr. Xu completed a fellowship in Hematopathology at Washington University in St. Louis.

In July 2013, Dr. Xu joined the faculty at VA San Diego Healthcare System and was appointed as Health Sciences Assistant Professor of Pathology at UCSD.  He was promoted to HS Associate Professor in 2017. He has served as the Site Director for Medical Education at VA San Diego.  His clinical responsibilities include hematopathology, surgical pathology, flow cytometry and medical directorship of clinical laboratories.

Dr. Xu has received many honors and awards, including: American Heart Association Research Fellowship; Neurosurgery Neuroscience Consortium Fellowship; the Sidney Saltzstein Award for Patient Care; the David J. Epstein Award for Research Excellence; the Whitehill Prize for excellence in clinical teaching.

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