DEPARTMENT OF PATHOLOGY

Scott VandenBerg, M.D., Ph.D.

Scott VandenBerg, M.D., Ph.D.

  • Professor
  • Director of Neuropathology
  • Director,  Human Tissue Technology Core and UCSD CTRI Human Tissue Resources

  • M.D., Ph.D. - Stanford University, 1979
  • Internship in Pathology, University of Colorado Health Sciences Center
  • Resident in Anatomic Pathology and Neuropathology Fellowship, University of Virginia
  • Postdoctoral Training -- Laboratory of Developmental Neurochemistry, Stanford University School of Medicine

Research Interests

Gliomas present a wide spectrum of biologic behavior with respect to properties of cellular motility and invasive tumor cell dispersion within the neuraxis. The VandenBerg laboratory studies the interactive roles of chemokines, LRP-1 signaling and proteinase activity at the cell surface as determinants of cellular chemokinesis and invasive chemotaxis in low and high grade gliomas.
His translational research, as Director of the Laboratory for Human Tissue Technology focuses on the application of multiple proteomic, epigenetic and genetic techniques for the molecular morphologic analysis of biomarkers in CNS tumor sections. The technologies include processing techniques for tissue to preserve analyte quality for RNA, DNA and proteomics with optimal histologic quality and multiple detection modalities on tissue sections for biomarker multiplexing in heterogeneous tumors, including the genomic and proteomic characterization of prognostic markers in CNS tumors.

Representative Publications

  1. Otero J.J., Rowitch D., VandenBerg S. (2010) OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms. J Neurooncol. 104:423-438.
  2. Hu J., Jo M., Cavenee W.K., Furnari F., VandenBerg S.R., Gonias S.L. (2011) Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. PNAS. 108:15984-15989.
  3. Fenton T.R., Nathanson D., Ponte de Albuquerque C., Kuga D., Iwanami A., Dang J., Yang H., Tanaka K., Oba-Shinjo S.M., Uno M., del Mar Inda M., Wykosky J., Bachoo R.M., James C.D., DePinho R.A., VandenBerg S.R., Zhou H., Marie S.K., Mischel P.S., Cavenee W.K., Furnari F.B. (2012) Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine PNAS 109:14164-14169.
  4. Stoletov K., Strnadel J., Zardouzian E., Momiyama M., Park F.D., Kelber J.A., Pizzo D.P., Hoffman R., VandenBerg S.R., Klemke R.L. (2013) Role of connexins in metastatic breast cancer and melanoma brain colonization. J. Cell Sci. 126:904-913.
  5. Read R.D., Fenton T.R., Gomez G.G., Wykosky J., VandenBerg S.R., Babic I., Iwanami A., Yang H., Cavenee W.K., Mischel P.S., Furnari F.B, Thomas J.B. (2013) A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma. PLOS Genetics 9: 1-19.
  6. Lopes, M.B.S. and VandenBerg, S.R. (2013) Tumors of the Central Nervous System. In: Diagnostic Histopathology of Tumors 4th Edition (C.D.M. Fletcher, ed.) Saunders, Philadelphia.
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Biography

Dr. VandenBerg is Professor of Pathology and Director of the Neuropathology.  He was awarded an M.D. and Ph.D. in Neurosciences at Stanford University, and received training in Anatomic Pathology at the University of Colorado Health Sciences Center and at the University of Virginia Health System. He completed his Neuropathology Fellowship with Lucien J. Rubinstein and also received postdoctoral training in the Laboratory of Developmental Neurochemistry with Roland Ciaranello at Stanford University.  In 1984 he joined the Division of Neuropathology at the University of Virginia as an Assistant Professor of Pathology and rose to the rank of Professor and Director of the Division of Neuropathology.  In 1998 he was named as the John T. and Louise Nerancy Professor of Neurosciences at the University of Virginia. In 2003, he moved to UCSF to become Professor of Pathology and Neurological Surgery, and Director of the Tissue Core of the Brain Tumor Research Center Tissue Core and the UCSF Neuropathology Biomarkers Laboratory. In this capacity, he also served as the Director of the UCSF Brain SPORE Tissue Core and in 2007, became a member of the GBM Working Group of the Cancer Genome Atlas Project to establish consensus histopathologic features for the TCGA data base.  In 2008, he became Co-Director of RTOG Biospecimen Resource for neurological pathology. In 2009, he joined the Department of Pathology, University of California San Diego as the Director of Neuropathology and now heads the newly established Human Tissue Technology Laboratory and the UCSD CTRI Human Tissue Repository.

While a M.D.-Ph.D. student, he won the Weil Award from the American Association of Neuropathologists in 1974 for best paper on experimental neuropathology. In 1990 he became a Charter Member of the Diagnostic Slide Session of the Association, and in 2004, he served as the Association’s Vice President. He has co-authored multiple textbook chapters on the histopathology of nervous system tumors and has characterized a number of novel tumor phenotypes, including the desmoplastic infantile ganglioglioma. He has collaborated with the NABTC Consortium, the Glioma Marker Network, and was a member of the World Health Organization Meeting in March 1990 on the Histological Typing of Tumors of the CNS and has contributed to subsequent editions of the World Health Organization series on the histological and genetic typing of human brain tumors.

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