DEPARTMENT OF PATHOLOGY

Celsa A. Spina, Ph.D.

  • Associate Professor
  • Research Microbiologist Division of Infectious Diseases
  • VA San Diego Healthcare System
  • Ph.D. - University of California, Davis

Research Interests

Basic research on the influence of T cell activation events in the regulation of HIV replication and the interaction of viral gene product, nef with components of required activation events. Applied, clinical research on the association and influence of T cell subsets in the progression of HIV infection in AIDS.

Representative Publications

  1. Papagno L, Spina CA, Marchant A, Salio M, Rufer M, Little S, Dong T, Chesney G, Waters A, Easterbrook P, Dunbar PR, Shepherd D, Cerundolo V, Emery V, Griffiths P, Conlon C, McMichael AJ, Richman DD, Rowland-Jones SL, and Appay V. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2:173-185, 2004.
  2. Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, Jones EY, and Rowland-Jones SL. HIV-specific cytotoxic T cells from long-term survivors select a unique T-cell receptor. J. Exp. Med. 200:1547-1557, 2004.
  3. Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina CA, Richman DD, and Wong JK. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J. Infect. Dis. 191:1410-1418, 2005. From Work in Progress
  4. Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, and Margolis, DM. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366:549-555, 2005.
  5. Stone GW, Barzee S, Snarsky V, Kee K, Spina CA, Yu X-F, and Kornbluth RS. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for Human Immunodeficiency Virus DNA vaccines. J. Virol. 80:1762-1772, 2006.
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Biography

Dr. Spina graduated from the University of California, Davis with a Ph.D., Microbiology. Her Postgraduate work was done with John L. Fahey, M.D. at the University of California, Los Angeles as a Postdoctoral Research Fellow in the Department of Microbiology & Immunology.

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