G. Diane Shelton, D.V.M, Ph.D.

G. Diane Shelton, D.V.M, Ph.D.

  • Professor
  • Ph.D. - University of California, Davis
  • Clinical Specialty: Neuromuscular diseases of companion animals

Research Interests

Mechanisms of autoimmunity in myasthenia gravis and inflammatory myopathies. Research in canine models of these diseases has direct relevance to their human counterparts.

The Comparative Neuromuscular Laboratory is a self-supporting international reference center for the diagnosis and study of neuromuscular diseases affecting companion animals. Six full time Staff Research Associates are employed by the laboratory to perform diagnostic clinical and research testing procedures on muscle and nerve biopsy specimens. Serological assays are also performed for the diagnosis of canine and feline myasthenia gravis. A large tissue archive of frozen and embedded muscle and nerve specimens is maintained. Consultations and collaborations are also available to other investigators using rodent models of neuromuscular disease.

Representative Publications

  1. Jones BR, Brennan S, Mooney CT, Callanan JJ, McAllister H, Guo LT, Martin PT, Engvall E, Shelton GD (2004). Muscular dystrophy with truncated dystrophin in a family of Japanese Spitz dogs. J Neurol Sci 217:143-149.
  2. Pumarola M, Moore PF, Shelton GD (2004). Canine inflammatory myopathy: analysis of cellular infiltrates. Muscle Nerve 29:782-789.
  3. Salvadori C, Peters IR, Day MJ, Engvall E, Shelton GD (2005). Muscle regeneration, inflammation, and connective tissue expansion in canine inflammatory myopathy. Muscle Nerve 31:192-198.
  4. Shelton GD, Engvall E (2005). Canine and feline models of human inherited muscle diseases. Neuromusc Disord 15:127-138.
  5. Li Z-F, Shelton GD, Engvall E (2005). Elimination of myostatin does not combat muscular dystrophy in dy mice but increases postnatal lethality. Am J Pathol 166:491-497.
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Dr. Shelton is a 1979 graduate of the School of Veterinary Medicine, University of California, Davis. Following an internship in small animal medicine and surgery at Michigan State University and a residency in small animal internal medicine at the University of Pennsylvania, she became board certified by the American College of Veterinary Internal Medicine. She returned to UC Davis where she completed a PhD program in Comparative Pathology in 1985. Pursing an interest in myasthenia gravis, Dr. Shelton was a post-doctoral fellow in the Receptor Biology Laboratory at the Salk Institute in La Jolla from 1985-1990. Dr. Shelton then moved to UC San Diego where she became a member of the Department of Pathology and established the Comparative Neuromuscular Laboratory. She is currently Professor in the Department of Pathology and Director of the Comparative Neuromuscular Laboratory.

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