DEPARTMENT OF PATHOLOGY

Subhojit Roy, M.D., Ph.D.

Mana M. Parast, M.D., Ph.D.

  • Associate Professor
  • Residency/fellowship - University of Pennsylvania
  • Ph.D. - Temple University
  • Board Certifications: Anatomic Pathology and Neuropathology

Research Interests

The Roy lab is generally interested in neuronal trafficking - how things move around in neurons. There are two overall focus areas:


1. Cell Biology of Neuronal trafficking/transport: Due to their complex geometry and finite sites of bulk protein synthesis (perikarya), neurons have evolved elaborate transport and trafficking machineries to deliver proteins into axons and dendrites. How are somatically-synthesized proteins delivered to their appropriate sites, and then retained there (for example at the synaptic terminal)? Knowledge into the biology of this process is critical to our understanding of neuronal form and function.

2. Cell Biology of Neurodegeneration: There is general consensus that that amyloid-beta and tau are key proteins involved in Alzheimer's disease, and that alpha-synuclein is intimately involved in Parkinson's disease (whether they are pathogenic or not). Yet, a major gap in our understanding relates to the precise pathways by which these proteins induce neuronal dysfunction - particularly initiating mechanisms, and how/where the various pathologic proteins operate in a given pathologic cascade. We believe that these questions can be answered by high-fidely cellular models that accurately capture key pathologic features of these diseases - for example synaptic dysfunction. Below is a generic description of some of the current projects.

See www.roylab.org for more information.

Funding

NIH, Larry Hillblom foundation, Alzheimer's Association, American Federation for Aging Research, American Parkinson's Disease Association and the March of Dimes.

Media Coverage

UC San Diego Researchers Answer Key Alzheimer’s Question
Why Don't We All Get Alzheimer's Disease?

Representative Publications

  1. A pathologic cascade leading to synaptic dysfunction in α-synuclein-induced neurodegeneration (2010). Scott D, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S^*. Journal of Neuroscience Jun 2010 16;30(24):8083-95.
  2. Mechanistic logic underlying the axonal transport of cytosolic proteins. Scott D, Das U, Tang Y and Roy S^*. Neuron May 2011 12;70(3):441-54.
    *Preview: "The Curious Case of the Soluble Protein". Brady, ST. Developmental Cell. 2011 May 17;20(5):581-2.
  3. Click here to search for Dr.Roy's publications

Biography

Dr. Roy is also a member of the Graduate Program in Neurosciences at UCSD. He is Board Certified in Anatomic Pathology and Neuropathology, is the attending neuropathologist at the Veterans affairs (VA) hospital and shares clinical neuropathology responsibilities at other UCSD hospitals.

Click here to contact me

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