DEPARTMENT OF PATHOLOGY

 

Bettina G. Papouchado, M.D.

Bettina G. Papouchado, M.D.

  • Assistant Professor
  • M.D. - University of Buenos Aires, Argentina
  • Postdoctoral Fellow: Immunology, Mayo Clinic, Rochester, MN
  • Residency: Mayo Clinic, Rochester, MN and Cleveland Clinic, Ohio
  • Cytopathology Fellowship: Cleveland Clinic, Ohio
  • Board Certifications: Anatomic Pathology and Cytopathology
  • Clinical Specialty: Diagnostic surgical pathology, Cytopathology, breast and gastrointestinal pathology

Research Interests

My research was primarily focused in finding the best molecular technic for the determination of HER2 status in breast cancer. I demonstrated that SISH, a newly introduced silver enhanced in-situ hybridization method, offered a convenient method for the assessment of HER2 gene amplification status in breast carcinoma with several advantages over the other methodologies in current clinical use.

I have also been actively involved in several research projects in collaboration with Dr. Feldstein’s lab.  My work has encompassed the fundamental mechanisms of liver injury by fatty acids which resulted in several peer-reviewed publications in top-medical journals . I was specifically involved in the evaluation of the liver histopathology and grading scoring system in various experimental models for non-alcoholic steatohepatitis (NASH).  We evaluated the role of different pro-inflammatory molecules in liver injury, apoptosis, and fibrosis. These findings have important implications for NASH pathogenesis and the development of novel therapeutic strategies for patients with this condition.

Representative Publications

  1. BG Papouchado, J Myles, RV Lloyd, M Stoler, AM Oliveira, E Downs-Kelly, A Morey, M Bilous, R Nagle, N Prescott, L Wang, L Dragovich, A McElhinny, C Ferrell Garcia, J Ranger-Moore, H Free, W Powell, M Loftus, J Pettay, F Gaire, C Roberts, M Dietel, P Roche, T Grogan and R Tubbs. Silver in situ Hybridization (SISH) for Determination of HER2 Gene Status in Breast Carcinoma: Comparison with FISH and Assessment of Inter-Observer Reproducibility. Am J Surg Pathology 34 (6); 767-76, 2010.
  2. Dixon LJ, Berk M, Thapaliya S, Papouchado BG, Feldstein AE. Caspase-1-mediated Regulation of Fibrogenesis in Diet-induced Steatohepatitis. Lab Invest. 2012 May;92(5):713-23. doi: 10.1038/labinvest.2012.45. Epub 2012 Mar 12.00:1-11, 2012.
  3. Dixon LJ, Flask CA, Papouchado BG, Feldstein AE, Nagy LE. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One. 2013; 8(2):e56100. doi: 10.1371/journal.pone.0056100. Epub 2013 Feb 7.
  4. Lazic M, Eguchi A, Berk MP, Povero D, Papouchado B, Mulya A, Johnson CD, Feldstein AE. Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice. J Hepatol. 2014 Jul;61(1):107-15. doi: 10.1016/j.jhep.2014.03.028. Epub 2014 Mar 27.
  5. Thapaliya S1, Wree A, Povero D, Inzaugarat ME, Berk M, Dixon L, Papouchado BG, Feldstein AE. Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model. Dig Dis Sci. 2014 Jun;59(6):1197-206. doi: 10.1007/s10620-014-3167-6. Epub 2014 May 3.
  6. Navarro LA, Were A, Povero D, Berk MP, Eguchi A, Ghosh S, Papouchado BG, Erzurum SC,Feldstein AE. Arginase 2 deficiency results in spontaneous steatohepatitis: a novel link between innate immune activation and hepatic de novo lipogenesis. J Hepatol. 2015 Feb;62(2):412-20. Epub 2014 Sep 16.
  7. Povero D, Panera N, Eguchi A, Johnson CD, Papouchado BG, de Araujo Horcel L, Pinatel EM, Alisi A, Nobili V, Feldstein AE. Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):646-663.e4.

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Biography

Dr. Papouchado received her medical degree at the University of Buenos Aires, in Argentina. She subsequently completed a post-doctoral fellowship in the Department of Immunology, at the Mayo Clinic.  She then started her Anatomic and Clinical Pathology residency at the Mayo Clinic, where she completed 40 month of training.   She continued her training in Anatomic and Clinical Pathology at the Cleveland Clinic followed by a Fellowship in Cytopathology. In 2006, Dr. Papouchado joined the Cleveland Clinic as Staff in the Department of Pathology. Her clinical interests were in diagnostic cytology and breast pathology.  Her research was primarily focused in finding the best molecular technic for the determination of HER2 status in breast cancer. In August 2011, Dr. Papouchado joined the faculty at the VA San Diego Healthcare System and was appointed as Assistant Clinical Professor at UCSD.

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