DEPARTMENT OF PATHOLOGY

Dzung Le, M.D., Ph.D.

Dzung Le, M.D., Ph.D.

  • Associate Professor
  • Director of the Coagulation Laboratory
  • Associate Director of the Clinical Hematology Laboratory
  • Associate Director of Blood Bank and Transfusion Medicine
  • Ph.D. - University of California, San Diego
  • M.D. - Mount Sinai School of Medicine New York
  • Clinical Speciality: Hemostasis and thrombosis

Research Interests

Under my direction, the UCSD Special Coagulation Laboratory serves as the reference coagulation laboratory for UCSD Medical Center patients and surrounding community hospitals and private physicians. My research interests are tissue factor-initiated coagulation pathway and clinical coagulation assay development. My research laboratory, located in the La Jolla campus, also houses the Murine Hematology/Chemistry and Coagulation Core laboratory. This core laboratory tests for abnormalities in hematology, chemistry and coagulation in experimental mice (e.g., transgenic mice).

Representative Publications

  1. Dzung The Le, Samuel I. Rapaport, and L. Vijaya Mohan Rao. Studies of the Mechanism for Enhanced Cell Surface Factor VIIa/Tissue Factor Activation of Factor X on Fibroblast Monolayers after Their Exposure to N-Ethylmaleimide. Thromb. Haemostas. 72:848-855, 1994.
  2. Dzung The Le, Kathleen J. Donnelly, Ning Wu, Babara K. Sevilla, and Samuel I. Rapaport. Reliability of a Modified Tissue Factor-dependent Factor V Assay for Activated Protein C Resistant Factor Va Using a Calcium-Containing Thromboplastin. Thromb. Haemostas. 77:481-485, 1997.
  3. Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT,Marth JD. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 99(15):10042-7, 2002.
  4. Wahrenbrock M, Borsig L, Le D, Varki N, Varki A. Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest. 112(6):853-62, 2003.
  5. Amoureux MC, Hegyi E, Le D, Grandics P, Tong H, Szathmary S. A new method for removing endotoxin from plasma using hemocompatible affinity chromatography technology, applicable for extracorporeal treatment of septic patients. J Endotoxin Res.
  6. Click here to search for Dr. Le's publications

Biography

Dzung The Le received his Bachelor of Science degree in Chemistry "summa cum laude" from California State Polytechnic University (Pomona, California) in 1979. He received his Master of Science degree in Biochemistry in 1982 and his Doctor of Philosophy degree in Biochemistry in 1985, both from UCSD. He received his Doctor of Medicine degree from Mount Sinai School of Medicine (New York, New York) in 1989. He completed his residency in Clinical Pathology at UCSD. He is board certified in Clinical Pathology (American Board of Pathology) . In 1992 Dr. Le was appointed Assistant Adjunct Professor of Pathology at UCSD. In 1994 he was appointed Assistant Professor of Pathology in Residence. He was appointed as Associate Professor of Clinical Pathology in 2001.

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