Research

Teachingstevan_courses.html
Gagneux Lab
Department of Pathology, UCSDGagneux_Lab_UCSD.html

Stevan Springer

stevan.springer@gmail.com

 

I study phenotypic effects of genetic changes

to infer mechanisms of adaptive evolution

in natural populations

09

2011

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07

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04

03

Environment-specific heterozygote deficiency and developmental instability in hybrid Mytilus 
Springer SA and Heath DD 
Mar Biol Res 2007 3:182-187https://www.dropbox.com/s/olgz5rs2kcrs5gb/07_springer_environment.pdf

02

Implications of the Copernican Principle for my Masters thesis 
Springer SA 
Ann Improb Res 2004 10.4:20-21https://www.dropbox.com/s/2klo69rwdr0jsoi/04_springer_copernican.pdf

01

Social slime molds meet their match 
Crespi B and Springer S 
Science 2003 299:56-57https://www.dropbox.com/s/1da954fiohts9vo/03_crespi_social.pdf

2009

2008

2007

2004

2003

Curriculum Vitaehttps://www.dropbox.com/s/tgnfxf64pt3ni1i/Stevan%20Springer-CV-Academic.pdf

Organismal behavior in molecular detail

I use experimental and computational

tools to study molecular systems:

how their changes influence behavioral phenotypes and what their evolution can tell us about adaptation

11

2013

10

Duplicate abalone egg coat proteins bind sperm lysin similarly, but evolve oppositely, consistent with molecular mimicry at fertilization
Aagaard JE, Springer SA, Soelberg SD, 
Swanson WJ
PLoS Genetics 2013 9(2): e1003287https://www.dropbox.com/s/vr4tnxcaefakh7h/13_aagaard_duplicate.pdf
Glycan evolution in response to collaboration, conflict, and constraint
Springer SA, Gagneux P
JBC 2013 28:6904-6911https://www.dropbox.com/s/njgclv5zkox1st6/13_springer_glycan.pdf
Adaptive gamete-recognition divergence in a hybridizing Mytilus population 
Springer SA and Crespi BJ 
Evolution 2007 61:772-783https://www.dropbox.com/s/ir5t98q8tj4zl1w/07_springer_adaptive.pdf
Extraordinary intraspecific polymorphism in oyster sperm bindin 
Moy GW*, Springer SA*, Adams SL, Swanson WJ, Vacquier VD  
PNAS 2008 105:1993-1998https://www.dropbox.com/s/3p2wid09dy5knqk/08_moy_extraordinary.pdf
Oyster sperm bindin is a combinatorial fucose lectin with remarkable intra-species diversity 
Springer SA, Moy GW, Friend DS, Swanson WJ, Vacquier VD  
Int J Dev Biol 2008 52:759-768https://www.dropbox.com/s/kjh8jl0ft9ziguq/08_springer_oyster.pdf
Coevolution of interacting fertilization proteins
Clark NL, Gasper J, Sekino M, Springer SA, Aquadro CF, Swanson WJ 
PLoS Genetics 2009 5(7): e1000570https://www.dropbox.com/s/k6vrntp67nleyiz/09_clark_coevolution.pdf
Beyond the phenotypic gambit: molecular behavioral ecology and the evolution of genetic architecture
Springer SA, Crespi BJ, Swanson WJ 
Molecular Ecology 2011 20:2240-2257https://www.dropbox.com/s/bw6m9b8tdrbcdtx/11_springer_beyond.pdf
Sexual selection by female immunity against paternal antigens can fix loss of function alleles
Ghaderi D*, Springer SA*, Ma F*, Cohen M, 
Secrest P, Taylor R, Varki A, Gagneux P
PNAS 2011 108:17443-17448https://www.dropbox.com/s/y38e0uec6z657za/11_ghaderi_sexual.pdf

12

2014

Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc
Springer SA, Diaz SL, Gagneux P
Immunogenetics 2014 66:671-674https://www.dropbox.com/s/5edjv7yem2fg3aw/14_springer_parallel.pdf

15

Human-specific derived alleles of CD33 and other
genes protect against postreproductive
cognitive decline
Schwarz F, Springer SA, Altheide T, Varki NM, Gagneux P,Varki A  
PNAS 2016 113:74-79stevan_files/16_schwarz_human.pdf

2016

Distinguishing spandrels and phenotypic targets of molecular evolution

Springer SA, Manhart M, Morozov AV

Biodiversification from Genotype to Phenotype

2016 (in press)

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13

2015

Evolutionary analysis and classification of OATs, OCTs, OCTNs, and SLC22 transporters
Zhu C, Nigam KB, Date RC, Springer SA, Saier MH, Wu W, Nigam SK 
PLoS One 2015 10(11): e0140569stevan_files/small_15_zhu_SLC22.jpg

Des variations génétiques nouvelles préservent l'esprit des personnes âgées

Springer SA, Gagneux P

Médicine et Science 2016 (in press)

17

Maintenance of postreproductive cognitive capacity by inclusive fitness
Springer SA, Schwartz F, Altheide T, Varki NM, Varki A, Gagneux P (2016) 
PNAS 2016 doi:10.1073/pnas.1601419113https://www.dropbox.com/s/4b5xzylhf5ayaz4/16_springer_maintenance.pdf

16

Glycomics: revealing the dynamic ecology and evolution of sugar molecules
Springer SA, Gagneux P 
Journal of Proteomics 2016 135:90-100stevan_files/small_16_springer_glycomics.jpg

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