Eillen Tecle

etecle@ucsd.edu

Gagneux Lab
Department of Pathology, UCSDGagneux_Lab_UCSD.html
 

I study how sialic acids influence immune response in the female reproductive system after mating. I use both genetic and biochemical approaches, to determine how sialic acids, sialidases and siglecs (sialic acid binding Ig-like lectins) influence the survival and success of sperm in the female reproductive tract.

I study how sialic acids modulate

female immunity during reproduction

Publications

01

Recent integrations of mammalian Hmg retropseudogenes
Tecle E, Zielinski L, and Kass D.H. (2006)
Journal of Genetics 2006 85:179-185eillen_files/Cohen2003_Bioph.pdf

02

Kass D.H., Jamison N., Mayberry M.M., and Tecle E
Identification of a unique Alu-based polymorphism and its use in human population studies Gene 2007 390:146-152eillen_files/Cohen2003_Bioph_1.pdf

03

Tecle E, Diaz-Balzac CA, and Bülow HE 
Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1 dependent neurite branching in a context-dependent manner in Caenorhabditis elegans
G3 2013 3:541-52.eillen_files/Cohen2003_Bioph_2.pdf

04

Salzberg Y, Diaz-Balzac CA, Ramirez N, Attreed M, Tecle E, Desbois M, Kaprielian 
Z, and Bülow HE
Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans
Cell 2013 155:308-320eillen_files/Cohen2003_Bioph_3.pdf

Teaching

Molecular Genetics Tutorial

I led class wide and small group tutorial sessions for the Molecular Genetics class at the Albert Einstein College of Medicine on yeast, C. elegans, Drosophila, mouse and human genetics.

Graduate Biochemistry Tutorial

I led class wide tutorial sessions for the Graduate Biochemistry I class at the Albert Einstein College of Medicine on DNA synthesis and transcription.

2010

2009

2008  

2008

Tecle, E and Gagneux, P
Sugar coated sperm: unraveling the functions of the mammalian sperm glycocalyx. Molecular Reproduction and Development. In press.eillen_files/Schwarz_etal2015eLife.pdf

05

Detection of the dietary xenoglycan N-glycolylneuraminic acid (Neu5Gc) and anti-Neu5Gc antibodies within reproductive tracts of male and female infertility subjects.
Sroga JM, Wu DH, Ma F, Tecle E, Reynoso HS, Ressler IB, Maxwell R, Ferrari R, Whigham L, Gagneux P, Lindheim S. 2015.  Clin Obstet Gynecol Reprod Med 2015eillen_files/SrogaetalXenoglycan%26HumanInfertility2015.pdf

06