DEPARTMENT OF PATHOLOGY

Patricia Kopko, M.D.

Patricia Kopko, M.D.

  • Professor
  • Director of Transfusion Medicine
  • Associate Director of the Immunogenetics and Transplantation Laboratory
  • M.A., Brandeis University
  • M.D., Loma Linda University
  • Residency Training: Loma Linda University Medical Center
  • Fellowship Training: Cedars-Sinai Medical Center, Transfusion Medicine

Research Interests

Dr Kopko’s research interests center around transfusion reactions, particularly Transfusion-Related Acute Lung Injury (TRALI). TRALI is currently the leading cause of transfusion-related mortality in the United States. The presence of HLA antibodies in donated blood components is an important cause of TRALI. Dr. Kopko is interested in making the blood supply safer by reducing the risk of TRALI from donated blood. She is also interested in the mechanism of action of how HLA antibodies and other factors cause this reaction in transfused patients.

Representative Publications

  1. Kopko, PM, Marshall CS, MacKenzie MR, et al. Transfusion-related acute lung injury: report of a clinical look-back investigation. JAMA 2002;287:1968-71.
  2. Hutchinson K, Kopko PM, Muto KN, et al. Early diagnosis and successful treatment of a patient with transfusion-associated GVHD with autologous peripheral blood progenitor cell transplantation. Transfusion 2002; 42:1567-72.
  3. Kopko PM, Paglieroni PM, Popovsky MA, et al, TRALI: correlation of antigen-antibody and monocyte activation in donor-recipient pairs. Transfusion 2003;43:177-84.
  4. Kopko P, Silva M, Shulman I, Kleinman S. AABB survey of transfusion-related acute lung injury policies and practices in the United States. Transfusion 2007;47:1679-85.Kleinman S, Grossman B, Kopko P. A national survey of transfusion-related acute lung injury risk reduction policies for platelets and plasma in the United States. Transfusion 2010;50:1312-21.
  5. Click here to search for Dr.Kopko's publications

Biography

Dr. Kopko received a BA in Chemistry from Brandeis University in 1986. She received an MD from Loma Linda University, where she also completed a post-sophomore year in pathology, in 1991. She remained at Loma Linda University Medical Center for a residency in Anatomic and Clinical Pathology. She completed a Transfusion Medicine Fellowship at Cedars-Sinai Medical Center in Los Angeles in 1996. She was an Assistant Professor in the Department of Pathology at the University of California, Los Angeles from 1996 to 1997. In 1997 she became Associate Medical Director of BloodSource, a regional not for profit blood center located in Sacramento California. While at BloodSource she completed training to become a Histocompatibility Laboratory Director. She became Chief Medical Officer/Executive Vice President of Medical Affairs of BloodSource in 2004. She became Director of the BloodSource Histocompatibility Laboratory in 2006. During her time in Sacramento, she was an Assistant Clinical Professor in the Department of Medical Pathology at the University of California, Davis. She became Associate Director of the Transfusion Medicine and Immunogetics and Transplantation Laboratories at UCSD in 2011.

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