DEPARTMENT OF PATHOLOGY

Richard L. Klemke, Ph.D.

Richard L. Klemke, Ph.D.

  • Professor, Department of Pathology and Moores Cancer Center
  • Ph.D. - Texas Tech University Health Science Center

Research Interests

Signal transduction, mechanisms of cell migration and invasion.
Click here for information on the Klemke Lab.

Representative Publications

  1. Wang, Y., Yang, F., Huang, X., Wang, W., Jiang, X., Gritsenko, M.A., Zhao, R., Monore, M.E., Pertz, O.C., Purvine, S.O., Orton, D.J., Jacobs, J.M., Camp, D.G. 2nd, Smith, R.D. & Klemke, R.L. Spatial phosphoprotein profiling reveals a compartmentalized ERK switch governing neurite growth and retraction. J Biol Chem, 286(20), 18190-201. 2011.
  2. Wang, Y., Cao, H.S.T., Cantin, G.T., Lin, R., Wang, W., Kaushal, S., Kelber, J., Edgington, T.S., Hoffman, R.M., Bouvet, M., Yates, J.R. & Klemke, R.L.Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. PNAS, 107(24): 10920-5. 2010.
  3. Pertz, O., Wang,Y., Yang, F., Wang, W., Gay, L.J., Gristenko, M.A., Clauss, T.R., Anderson, D.J., Liu, T., Auberry, K.J., Camp, D.G.2nd, Smith, R.D. &Klemke, R.L. Spatial Mapping of the Neurite and Soma Proteomes Reveals A Functional Cdc42/Rac Regulatory Network.  PNAS, 105(6): 1931-6. 2008. Faculty 1000 Score 6.0.
  4. Stoletov, K., Montal, V., Lester, R., Gonias, S. & Klemke, R.L. High Resolution Imaging of the Dynamic tumor Cell-Vascular Interface in Transparent Zebrafish. PNAS, 104(44): 17406-11. 2007. Faculty 1000 Score 6.0.
  5. Wang, Y., Ding, S., Wang, W., Jacobs, J., Qian, W., Moore, R., Yang, F., Camp, D., Smith, R. & Klemke, R. Profiling signaling polarity in chemotactic cells. PNAS, 104(20): 8328-33. 2007. (Cell Biology). Faculty 1000 Score 6.0.
  6. Click here to search for Dr. Klemke's publications

Biography

Dr. Klemke received his BS degree in Biology from Hardin-Simmons University in Abilene, Texas, his MS degree from the University of Tulsa, and his PhD in Cell and Developmental Biology from Texas Tech University Health Sciences Center. From 1993 - 1998, Dr. Klemke was a research associate at The Scripps Research Institute, during which he defined his future career in cell adhesion and cell migration. His publications as a post-doctoral fellow identified a number of major cell-signaling pathways that are involved in cell migration. Working with Dr. David Cheresh, Dr. Klemke defined a concept in cell biology (involving compartmentalization of cell-signaling proteins in the migrating cell), which subsequently evolved into a major focus for Dr. Klemke as an independent investigator. Dr. Klemke was promoted at TSRI to Assistant Professor in the Department of Immunology in 1998, and then to Associate Professor in 2003. He joined UCSD as Professor of Pathology in 2006.

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