DEPARTMENT OF PATHOLOGY

Theo N. Kirkland, M.D.

Theo N. Kirkland, M.D.

  • Professor
  • Ph.D. - University of Alabama

Research Interests

Dr. Kirkland is a physician based at the VA Medical Center. He directs research projects concerning molecular mechanisms of septic shock and vaccine development. His special area of clinical expertise is Coccidioidomycosis, or Valley Fever.

Representative Publications

  1. Yu J-J, Kirkland TN, Hall LK, Wopschall J, Smith RC, Hung C-Y, Chen X, Tarcha E, Thomas PW, Cole GT: Characterization of a serodiagnostic complement fixation antigen of Coccidioides posadasil expressed in the nonpathogenic Fungus Uncinocarpus resii. J. Clin. Microbiol. 43(11):5462-5469 (2005)
  2. Kirkland TN, Raz E, Datta SK: Molecular and cellular mechanisms of protective immunity to coccidioidomycosis. Vaccine 24(4):495-500 (2006)
  3. Viriyakosol S, Matthias MA, Swancutt MA, Kirkland TN, Vinetz JM: Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 74(2):887-895 (2006)
  4. Viriyakosol S, Tobias PS, Kirkland TN: Mutational analysis of membrane and soluble forms of human MD-2. J.Biol.Chem. 281(17):11955-11964 (2006)
  5. Shubitz LF, Yu JJ, Hung CY, Kirkland TN, Peng T, Perrill R, Simons J, Xue J, Herr RA, Cole GT, Galgiani JN: Improved protection of mice against lethal respiratory infection with Coccididides posadasii using two recombinant antigens expressed as a single protein. Vaccine 24:5904-5911 (2006)
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Biography

Dr. Kirkland graduated from University of Alabama, School of Medicine. Postdoctoral Training was in Laboratory of Immunology at the National Institute of Allergy and Infectious Diseases, NIH. He then joined the faculty here at UCSD in La Jolla.

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