David A. Herold, M.D., Ph.D.

David A. Herold, M.D., Ph.D.

  • Professor
  • M.D. - University of Utah, 1979
  • Ph.D. - University of Utah, 1982
  • Board Certifications: American Board of Clinical Chemistry
  • Clinical Specialty: Clinical Chemistry

Research Interests

My laboratory research interests are in the area of mass spectrometry application to clinical diagnostics. This includes prostaglandins, trace metal and steroids. Additionally, we has been involved in the development and validation of "classical" clinical chemistry diagnostic tests. The application of the mass spectrometry to determine the validity of endocrine tests, in particular testosterone, has been of particular interest. We have been using GC-MS, LC-MS, and MS-MS techniques for these investigations. At the present time, we are involved with the use of Accelerator Mass Spectrometry for the determination of calcium flux in serum and urine using 41Ca as a marker. The purpose of these studies is to better understand bone remodeling in normal and diseased patients. We have also investigated the use of microfluidics for the application to clinical diagnostics to measure selected proteins in a rapid and accurate manner.

Representative Publications

  1. 1. O.T.M. Chan, D.A. Herold: "Chip Electrophoresis as a Method for Quantifying Total Microalbuminuria." Clinical Chemistry 52:2141-4146, 2006.
  2. R.L. Fitzgerald, D.J. Hillegonds, D.W. Burton, T.L. Griffin, S. Mullaney, J.S. Vogel, L. J. Deftos, D.A. Herold: " 41Ca and accelerator mass spectrometry to monitor calcium metabolism in end stage renal disease patients." Clinical Chemistry 51:2095-2102, 2005.
  3. L. Huang, G. Harvie, J.S. Feitelson, K. Gramatikoff, D.A. Herold, D.L. Allen, R. Amunagama, R.A. Hagler, M.R. Pisano, W.W. Zhang and X. Fang: "Immunoaffinity separation of plasma proteins by IgY microbeads: Meeting the needs of proteomic sample preparation and analysis." Proteomics 5:3314-3328, 2005.
  4. C.M. Lu, D.W. Burton, R.L. Fitzgerald, L.J. Deftos, B.A. Buchholtz, J.S. Vogel, and D.A. Herold: "Mass spectrometric immunoassay for parathyroid hormone-related protein." Analytical Chemistry 74:5507-5512, 2002.
  5. R.L. Fitzgerald, J.D. Rivera and D.A. Herold: "Broad spectrum drug identification directly from urine, using liquid chromatography-tandem mass spectrometry." Clinical Chemistry; 45:1224-1234, 1999.
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David Herold received his undergraduate degree in Chemistry from Tulane University. His post graduate educational background includes a MA in synthetic organic chemistry from the University of North Carolina Chapel Hill (1972), a Ph.D. in organic mechanistic mass spectrometry (1982), and a MD degree (1979) from the University of Utah and residency in Laboratory Medicine at the University of Virginia (1982). After completing residency training, he was then appointed Assistant Professor of Pathology. He received a promotion to Associate Professor in 1988. Dr. Herold joined UCSD as Associate Professor of Pathology In-Residence in 1991 and promoted to Professor In-Residence in 1997.

Dr. Herold's research has work in the area of mass spectrometry for over 30 years. He has developed application of gas chromatography-mass spectrometry (GC-MS) to the analysis of trace elements, prostaglandins and steroids. He has been involved in the field of automation and robotics. He co-founded the Association of Laboratory Automation serving as Program Chair and on the Board of Directors for 8 years.

Dr. Herold is a prolific publisher having contributed 72 research articles on topics spanning mechanistic and anlaytical mass spectrometry, toxicology and clinical chemistry.

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