DEPARTMENT OF PATHOLOGY

Joshua Fierer, M.D.

Joshua Fierer, M.D.

  • Professor
  • M.D. - New York University
  • Clinical Specialty: Medical Microbiology and Infectious Diseases

Research Interests

My research concerns innate immunity and the pathogenesis of Salmonella infections. We have been studying the immune response to Salmonella and the fungus Coccidioides immitis. We have use Salmonella and mouse mutants to help elucidate the complicated interplay between host and pathogen. We also use mutant mice to study coccidioidomycosis, emphasizing the role of pattern-recognition receptors in innate immunity.

Representative Publications

  1. Viriyakosol S, Fierer J, Brown GD, Kirkland TN. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun. 2005 Mar;73(3):1553-60. PMID: 15731053 [PubMed - in process]
  2. Asensi V, Valle E, Meana A, Fierer J, Celada A, Alvarez V, Paz J, Coto E, Carton JA, Maradona JA, Dieguez A, Sarasua J, Ocana MG, Arribas JM. In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis. Infect Immun. 2004 Jul;72(7):3823-8. PMID: 15213123 [PubMed - indexed for MEDLINE]
  3. Fierer J, Swancutt MA, Heumann D, Golenbock D. The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J Immunol. 2002 Jun 15;168(12):6396-403. PMID: 12055258 [PubMed - indexed for MEDLINE]
  4. Libby SJ, Lesnick M, Hasegawa P, Kurth M, Belcher C, Fierer J, Guiney DG. Characterization of the spv locus in Salmonella enterica serovar Arizona. Infect Immun. 2002 Jun;70(6):3290-4. PMID: 12011028 [PubMed - indexed for MEDLINE]
  5. Fierer J. Polymorphonuclear leukocytes and innate immunity to Salmonella infections in mice. Microbes Infect. 2001 Nov-Dec;3(14-15):1233-7. Review. PMID: 11755411 [PubMed - indexed for MEDLINE]
  6. Click here to search for Dr. Fierer's publications

Biography

Dr. Fierer graduated from NYU School of Medicine and then did a residency in Internal Medicine at Yale-New Haven Hospital, sandwiched around a two year stint in the Epidemic Intelligence Service at CDC. He did his Infectious Diseases Fellowship training with Abraham Braude at the University of Pittsburgh and then at UCSD. He joined the faculty at UCSD School of Medicine as an Assistant Professor in 1971 and has remained at that institution ever since.

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