DEPARTMENT OF PATHOLOGY

Lynette B. Corbeil, D.V.M., Ph.D.

Lynette Corbeil, D.V.M., PhD

  • Professor of Pathology UCSD
  • Emeritus Professor of Population Health and Reproduction School of Veterinary Medicine UC, Davis
  • Former Co-Director, UCSD Veterinary Medical Center
  • D.V.M. - University of Toronto, Ontario Veterinary College
  • Ph.D. - Cornell University
  • Specialty: Immunology; Infectious Disease

Research Interests

Our laboratory focuses on microbial virulence factors and in mucosal immunity to infections of the respiratory and reproductive tracts. Both antigen specificity and characteristics of protective immune responses are under investigation. Studies of the sexually transmitted disease, trichomoniasis, have resulted in purification of a major protective surface antigen. Protective immune responses in the female genital tract have been defined and development of inductive sites for IgA responses in the genital tract were documented for the first time. Recent studies of trichomonad extracellular cysteine proteinases as virulence factors are promising. For bovine Histophilus somni repiratory tract infection, we have defined the roles of IgG2 allotypes in protection and defined protective immunity to several virulence factors.  These include outer membrane proteins, lipooligosaccharide and a surface fibrillar network with immunoglobulin binding activity and a Fic containing domain that is cytotoxic for respiratory epithelial cells.  The recombinant Fic domain was shown to protect mice and cattle against H. somni disease.  Now we are studying viral/bacterial (BRSV/H. somni) synergyin respiratory disease and a new vaccine expression system.

Representative Publications

  1. Hoshinoo K, Sasaki K, Tanaka A, Corbeil LB, Tagawa Y. Virulence attributes of Histophilus somni with a deletion mutation in the ibpA gene. Microb Pathog. 46: 273-282, 2009
  2. Worby CA, Mattoo S, Kruger RP, Corbeil LB, Orth K, Koller A, Mendez JC, Zekarias B, Dixon, JE. The Fic domain: regulation of cell signaling by adenylylation. Molec Cell 34:93-103, 2009
  3. O’Toole D, Allen T, Hunter R, Corbeil LB. Acute myocarditis and histophilosis in feedlot cattle. Vet Pathol 46:1015–1017, 2009
  4. Cobo ER, Corbeil LB, Gershwin LJ, BonDurant RH. Preputial cellular and antibody responses of bulls vaccinated and/or challenged with Tritrichomonas foetus. Vaccine 28:361-370, 2010
  5. Zekarias B, Mattoo S, Worby C, Lehmann J,. Rosenbusch RF, Corbeil LB. Histophilus somni IbpA DR2/Fic in virulence and immunoprotection at the natural host alveolar epithelial barrier. Infect Immun 78: 1850-1858, 2010
  6. Zekarias B, O’Toole, Lehmann J, Corbeil LB. Histophilus somni IbpA cytotoxin is conserved in disease strains and most carrier strains from cattle, sheep and bison. Vet Microbiol, 149: 177-185, 2010
  7. Cobo ER, Corbeil LB, BonDurant RH. Immunity to infections in the lower genital tract of bulls. J Reprod Immunol 89: 55-61, 2011
  8. Geertsema RS, Zekarias B, Scheuch LL, Herdman DS, Lo K, Corbeil LB. IbpA DR2 subunit immunization protects calves against Histophilus somni pneumonia. Vaccine 28: 4805-4812, 2011
  9. Cobo ER, Eckmann L, Corbeil LB. Murine models of vaginal trichomonad infections. Am J Trop Med Hyg, 85:667-673, 2011
  10. Cobo ER, Reed SL, Corbeil LB. Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection. Internat J Antimicrob Agents 39: 259-62, 2012
  11. Lo KL, Kimball RA, Lehmann J, Gershwin C, Corbeil LB. Antibody responses of calves to Histophilus somni recombinant IbpA subunits. Comp Immunol Microbial Infect Dis, 35:453-459, 2012
  12. Click here to search for Dr. Corbeil's publications

Biography

Dr. Corbeil received her DVM degree from the Ontario Veterinary College, Univ. Toronto and her Ph.D. from Cornell University. She has held faculty positions at the Ontario Veterinary College, University of Guelph, School of Veterinary Medicine, Kansas State University, School of Veterinary Medicine, Washington State University, School of Veterinary Medicine, University of California, Davis and School of Medicine, University of California San Diego. From 2002 – 2010, she was the Co-Director of the UC Veterinary Medical Center – San Diego, a joint program of UC Davis and UCSD. She retired in 2012 but returned to active duty in the Pathology Department at UCSD to continue her research in microbial pathogenesis and protective immunity.

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