DEPARTMENT OF PATHOLOGY

H. Elizabeth Broome, M.D.

H. Elizabeth Broome, M.D.

  • Professor
  • Director of the Clinical Hematology Laboratory
  • Associate Director of the Immunogenetics and Transplantation Laboratory
  • M.D. - University of Pennsylvania
  • Clinical Specialty: Hematopathology

Research Interests

Regulation of leukemia and lymphocyte apoptosis. Growth of blood cells from embryonic stem cells.

Representative Publications

  1. Tanner ML, Hoh CK, Bashey A, Holman P, Sun C, Broome HE, Lane T, Ball ED, Carrier E. FLAG chemotherapy followed by allogeneic stem cell transplant using nonmyeloablative conditioning induces regression of myelofibrosis with myeloid metaplasia. Bone Marrow Transplant. 2003 Sep;32(6):581-5.
  2. Broome HE, Yu AL, Diccianni M, Camitta BM, Monia BP, Dean NM. Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs. Leuk Res. 2002 Mar;26(3):311-6.
  3. Broome HE, Dargan CM, Brunner T, Green DR. Sensitivity of S49.1 cells to anti-CD95 (Fas/Apo-1)-induced apoptosis: effects of CD95, Bcl-2 or Bcl-x transduction. Cell Death Differ. 1998 Mar;5(3):200-5.
  4. Broome HE, Dargan CM, Krajewski S, Reed JC. Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J Immunol. 1995 Sep 1;155(5):2311-7.
  5. Broome HE, Dargan CM, Bessent EF, Krajewski S, Reed JC. Apoptosis and Bcl-2 expression in cultured murine splenic T cells. Immunology. 1995
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Biography

Dr. Broome has a B.S. degree in Chemical Engineering from MIT and a M.D. degree from the University of Pennsylvania. After finishing a residency in Clinical Pathology and a fellowship in Hematopathology at the Hospital of the University of Pennsylvania, She became certified in Clinical Pathology with a specialty certification in Hematology from the American Board of Pathology. She joined the faculty at the University of California, San Diego in 1991, and is Director of the Clinical Hematology Laboratory at the UCSD Medical Center. Her research has focused on proteins that regulate lymphocyte and leukemia cell apoptosis.

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